NTP Research Concept: Di(2-ethylhexyl) Phthalate (DEHP) and Phthalate Mixtures
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چکیده
program prior to designing and conducting toxicology studies. The purpose of the research concept document is to outline the general elements of a research program that would address the specific public health concerns that prompted the nomination of the substance or issue for study. It may also encompass substance-specific studies that address larger public health issues or topics in toxicology. Additional information about the nomination, review, and selection of substances for study by the NTP is provided at Nominations to the NTP Testing Program (http://ntp.niehs.nih.gov/go/nom). A draft version of this research concept was reviewed by the NTP Board of Scientific Counselors at a public meeting on December 6, 2007 (http://ntp.niehs.nih.gov/go/9741) and subsequently revised.
منابع مشابه
The Effect of Di-(2-Ethylhexyl) Phthalate (DEHP) on Mouse Daily Sperm Production and Epididymal Sperm Parameters
Purpose: The purpose of this study is to evaluate the effect of Di-(2-ethylhexyl) phthalate (DEHP) on testicular spermatid number per gram testis (TSN), daily sperm production (DSP), count, motility, viability, morphology, and chromatine quality of epididymal sperm. Materials and Methods: The protocol for DEHP administration was that adult male NMRI mice (the age group of 4 weeks) received 29 D...
متن کاملDi-(2-ethylhexyl) phthalate induces precocious puberty in adolescent female rats
Objective(s): Nowadays, Di-(2-ethylhexyl) phthalate (DEHP) is widely used in different kinds of commercial products as a plasticizer. Previous studies have revealed that exposures to DEHP could be associated with precocious puberty in teenagers, but the exact mechanism is yet to be known. Materials and Methods: In this study, 48 prepubertal Wistar female rats were randomly apportioned into 4 gr...
متن کاملSelective Extraction and Determination of Di(2-ethylhexyl) Phthalate in Aqueous Solution by HPLC Coupled with Molecularly Imprinted Solid-phase Extraction
Surface Molecularly Imprinted Polymer (SMIP) for selective adsorption of di(2-ethylhexyl) phthalate(DEHP) was prepared on the surface of silica gel which was modified by aminopropyltriethoxysilane and acryloyl chloride in a two-step method. The prepared SMIP was used to prepare Molecularly Imprinted Solid-Phase Extraction (MISPE) column for selective extraction of DEHP from aqueous solution...
متن کاملInvestigation of Di-ethylhexyl Phthalate Migration by Applying Magnetic Solid Phase Extraction Method Followed by GC-FID Determination
Background and Objectives: The addition of plasticizers (mainly phthalates and adipates) makes plastic flexible and popular for packaging, storing and preserving food, water, and so on. The most widely used plasticizer in food contact applications is di-ethylhexyl phthalate (DEHP) though being suspected to have carcinogenic and estrogenic properties. The aim of this study is application of magn...
متن کاملIncreased Urinary Phthalate Levels in Women with Uterine Leiomyoma: A Case-Control Study
We assessed the urinary concentration of 16 phthalate metabolites in 57 women with and without uterine leiomyoma (n = 30 and 27; respectively) to determine the association between phthalate exposure and uterine leiomyoma. To evaluate exposure to di-(2-ethylhexyl) phthalate (DEHP); we calculated the molar sum of DEHP metabolites; ∑3-DEHP (combining mono-(2-ethylhexyl) phthalate (MEHP); mono-(2-e...
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